AI Breakthrough Turns 'Undruggable' Proteins into Treatment Targets

Researchers from Nobel Laureate David Baker's lab have developed AI-based methods to target intrinsically disordered regions (IDRs) in proteins, previously considered 'undruggable,' enabling new therapeutic possibilities for diseases like cancer, pain, and diabetes. These approaches use amino acid sequences to design high-affinity binders, overcoming previous challenges and expanding drug discovery horizons.