All articles tagged with #disordered proteins
Scientists have discovered that disordered gene-regulating proteins rely on a structured partner, beta-catenin, to function properly, challenging previous ideas about their chaotic nature and revealing a hidden organization that could impact understanding of gene control and disease.
Researchers from Nobel Laureate David Baker's lab have developed AI-based methods to target intrinsically disordered regions (IDRs) in proteins, previously considered 'undruggable,' enabling new therapeutic possibilities for diseases like cancer, pain, and diabetes. These approaches use amino acid sequences to design high-affinity binders, overcoming previous challenges and expanding drug discovery horizons.