"Uncovering a Hidden Layer of Human Gene Regulation with Pioneering Technique"

A pioneering technique called Long Range Cleavage sequencing (LORAX-seq) has been developed to detect and study the occurrence of "backtracking," a molecular event that influences gene regulation in humans and other species. This technique has revealed that backtracking occurs frequently throughout genomes, lasts longer than previously thought, and is associated with various gene types. The study suggests that persistent backtracking may play a crucial role in genetic regulation, including influencing cell division, tissue development, and histone control, while also potentially contributing to DNA damage and disease.