Unraveling Schizophrenia Mysteries: Insights from Gene Mutation

Scientists have developed a mouse model lacking the Grin2a gene, which closely mimics a rare genetic mutation associated with an increased risk of schizophrenia in humans. By studying this model, researchers have discovered significant changes in gene expression, brain cell activity, and neurotransmitter signaling, providing experimental evidence supporting the role of glutamate and dopamine in schizophrenia. The findings align with observed neurophysiological features in human patients and open up new avenues for therapeutic research and a deeper understanding of this debilitating mental disorder.