LSD's effect on the brain's "gatekeeper" explained by neuroscience research.

A new study published in Neuropsychopharmacology has found that LSD disrupts the brain's gatekeeping process, leading to increased information flow and altered perception. The study utilized data from two randomized, placebo-controlled, double-blind, cross-over trials involving a total of 45 healthy participants. The researchers found evidence that LSD resulted in widespread changes in both functional connectivity and effective connectivity. Additionally, LSD was found to enhance connectivity in brain areas associated with thinking and cognitive functions. The study raises the possibility that LSD may disrupt the balance between excitation and inhibition in the brain, a factor that has been linked to psychosis and hallucinatory experiences.