Lasting brain changes found in recovered COVID-19 patients, MRI study shows

A multimodal MRI study comparing Long COVID, recovered (symptom-free), and never-infected groups (47 participants) found distinct brain changes in tissue microstructure and neurochemistry associated with Long COVID and footprints in those who have fully recovered. Differences include altered myelin proxies (T1w/T2w) in motor and memory regions, diffusion changes in the cerebellum and brainstem, and metabolic shifts (lower glutamine, higher N-acetyl-aspartate) that correlated with physical function and cognitive scores. The study suggests SARS-CoV-2 may leave a brain footprint even after apparent recovery, but its cross-sectional design and small sample size mean longitudinal research is needed to determine permanence and timeline.