Tag

Synaptic Loss

All articles tagged with #synaptic loss

health1 year ago•2 min saved

"Potential Breakthrough: Blocking Key Protein Halts Alzheimer's Progression"

Researchers at the University of Colorado Anschutz Medical Campus have discovered that inhibiting a protein called Mdm2 with an experimental cancer drug can prevent the destruction of synapses and dendritic spines associated with Alzheimer's disease. This finding suggests a potential new approach to halting the progression of the disease, which could lead to future human trials and the development of new therapies.

via Medical Xpress|

#alzheimers-disease #experimental-drug #health

neuroscience2 years ago•65 min saved

Early Metabolic Changes in Alzheimer's Disease Revealed

A study using App knock-in mice, a model for Alzheimer's disease (AD), found that mitochondrial hypermetabolism occurs before the development of amyloid beta (Aβ) plaques. The study also observed impaired autophagy, declining mitochondrial function, neuroinflammation, and synaptic disturbances after the establishment of Aβ pathology. These findings suggest that mitochondrial alterations may occur in the early stages of AD and contribute to neuronal damage.

via Nature.com|

#alzheimers-disease #app-knock-in-mice #autophagy