Harnessing Double-Headed Molecules to Trigger Cancer Cell Self-Destruction

Researchers have developed a strategy to rewire cancer drivers and activate apoptosis, a process that leads to programmed cell death. By using small molecules to induce proximity between specific proteins, they were able to trigger the degradation of oncogenic transcription factors, such as BCL6, leading to the suppression of cancer cell growth. This approach shows promise as a potential therapeutic strategy for targeting cancer drivers and promoting apoptosis in cancer cells.