Tag

Targeted Delivery

All articles tagged with #targeted delivery

"Advancing Targeted Gene Editing: CRISPR Delivery Breakthroughs"

Originally Published 1 year ago — by Genetic Engineering & Biotechnology News

Scientists have developed enveloped delivery vehicles (EDVs) that can transport CRISPR genome editing tools to specific cells for precise genome engineering within living organisms. These EDVs, created by Nobel Prize winner Jennifer Doudna's lab, have the potential for widespread therapeutic use and were shown to successfully target and edit the genomes of human cells in both in vitro and in vivo experiments. The research establishes a programmable delivery method for genome editing and highlights the potential for targeted in vivo engineering of tissue-resident stem cells.

science science-and-technology crispr genome-editing in-vivo-engineering jennifer-doudna science-and-technology targeted-delivery

"Enhancing Targeted Biologic Delivery to T Cells through Genetically Encoded Extracellular Vesicles"

Originally Published 2 years ago — by Nature.com

Scientists have developed a method to genetically encode multiple functionalities into extracellular vesicles (EVs) for targeted delivery of biologics to T cells. EVs, such as exosomes, have shown promise as vehicles for therapeutic cargo delivery, but their targeting capabilities have been limited. By engineering EVs to express specific ligands or antibodies on their surface, researchers were able to enhance their binding and uptake by T cells. This approach could potentially improve the efficacy of T cell-based therapies and expand their applications in treating various diseases.

health biotechnology biologics biotechnology extracellular-vesicles genetic-engineering t-cells targeted-delivery