Tag

Retrovirus

All articles tagged with #retrovirus

science2 years ago

"Viral DNA: Essential for Embryonic Development"

Researchers from the CNIO have discovered that a virus that infected animals hundreds of millions of years ago plays a crucial role in the development of embryos. The viral genetic material integrated into the genome of the first multi-cellular beings is still present in our DNA today and is essential for the transition from totipotency to pluripotency in embryos. This finding has implications for regenerative medicine and artificial embryo creation, as it opens up new possibilities for generating stable cell lines in the totipotency phases. The study sheds light on the symbiotic co-evolution of endogenous retroviruses with host cells to ensure the smooth progression of early embryonic development.

health2 years ago

Unveiling the Ancient Virus Fueling Glioblastoma Brain Cancer

Reactivation of the dormant retrovirus HML-2 has been found to contribute to the aggressiveness and treatment resistance of glioblastoma, a type of brain tumor. The virus alters stem cell programming through a gene-regulating protein called OCT4, promoting a more aggressive form of cancer. Researchers have identified potential targets for developing more effective treatments, including an anti-retroviral drug that reduced HML-2 activity and tumor stem-cell markers. This discovery provides new insights into the molecular and cellular mechanisms of glioblastoma and offers a unique therapeutic target for combating this deadly brain cancer.