Scientists from Scripps Research identified a brain region in rats, the paraventricular nucleus of the thalamus (PVT), that becomes active during alcohol withdrawal and relapse, shedding light on how negative reinforcement drives addiction and potentially guiding new treatments.
Scientists at Scripps Research identified a brain circuit in the paraventricular nucleus of the thalamus that reinforces alcohol relapse by linking environmental cues with relief from withdrawal stress, offering new insights into addiction mechanisms and potential therapies.
A study from Scripps Research identifies the brain's PVT region as key in addiction, showing that alcohol relapse is driven by the brain's response to stress relief rather than pleasure, highlighting potential new treatment targets for substance use disorders.
Jim Irsay, the late Colts owner, secretly relapsed with substance abuse, including ketamine treatment, before his death in 2025, with allegations of a coverup by team officials and no toxicology tests or autopsy conducted.
Actress Christina Applegate opens up about her "pretty bad" relapse of multiple sclerosis on her new podcast, MeSsy, with fellow MS sufferer Jamie-Lynn Sigler. She describes the debilitating pain, sleeplessness, and deep depression she's experiencing, noting that her legs are "just done" and she hasn't showered in three weeks due to the constant pain and poor circulation. Applegate's candid discussion sheds light on the challenges of living with MS and the importance of being honest about its impact.
Author Bret Easton Ellis is set to make his directorial debut with the horror film "Relapse," starring Joseph Quinn. The film, produced by Paris-based SND, follows a man's struggle with addiction and a mysterious presence haunting him. Ellis, known for his novels like "American Psycho," has been involved in the movie world for years and describes "Relapse" as a personal, upscale monster movie with his signature themes. The film's creature will be designed by the Oscar-nominated VFX banner DDT Studios, and it will be a collaboration between Ellis, Quinn, and experienced producers.
A study in Schizophrenia Research suggests that adding acceptance and commitment therapy (ACT) to treatment for people with psychosis may lead to reduced distress and lower likelihood of re-hospitalization. Both ACT and 'treatment as usual' were found to reduce psychotic symptoms after four months, but those who did not receive ACT were significantly more likely to be re-hospitalized. The researchers believe that ACT may be feasible and effective for patients with psychosis, and could lead to decreased rehospitalization compared to alternative therapies.
Matthew Perry's ex-girlfriend, Kayti Edwards, speculates that the actor may have relapsed into drug use before his tragic death. Edwards claims that Perry's final Instagram post, where he referred to himself as "Mattman," was a sign of his drug use resurfacing. She also alleges that Perry had a history of using drugs in water and that he had a penchant for being in the water while under the influence. Edwards further claims that she was once Perry's assistant and would pick up drugs for him while she was pregnant. Perry's death, initially ruled as an apparent drowning, is being questioned by Edwards, who believes there may be more to the story.
Silent progression, also known as progression independent of relapse activity (PIRA), is a common phenomenon in multiple sclerosis (MS) where disability worsens without experiencing relapses. A review of studies suggests that PIRA accounts for at least 50% of reported instances of disability worsening in people with relapsing-remitting MS. Additionally, factors such as medication side effects, cost, and the form of treatment (injections, infusions, or pills) can influence MS patients' adherence to their treatments. The author questions the labeling of MS stages and emphasizes the importance of considering cost when making treatment decisions.
Scientists at the Indiana University School of Medicine have discovered that the supplementary motor cortex, an overlooked part of the brain, may play a critical role in determining the likelihood of relapse in individuals with drug use disorders. Through animal models, researchers found that hyperexcitability in this brain region can be modulated to potentially prevent relapse, offering a new avenue for treatment. This finding could lead to the development of less invasive methods, such as transcranial magnetic stimulation, to treat addiction and prevent relapse.
Individuals who have recovered from a major depressive episode exhibit a cognitive pattern characterized by a heightened focus on negative information and reduced attention to positive information, putting them at a higher risk for relapse. A meta-analysis of 44 studies involving over 4,000 participants revealed that those with a history of depression displayed a stronger bias towards processing negative stimuli compared to healthy controls. This cognitive imbalance suggests a decreased control over information processing and a predisposition towards negativity. The findings highlight the need for strategies to increase the processing of positive information in the treatment of depression.
A city councilman in Rhode Island, Matthew Reilly, was caught sleeping behind the wheel of his car with a crack pipe in his hand. Police found a bag of cocaine at the scene. Reilly, who is an attorney, also resigned as chairman of the Cranston Republican Party. He says he relapsed due to a bad divorce.