All articles tagged with #polyamines
Polyamines—molecules linked to longevity via autophagy and eIF5A1—also promote cancer by increasing eIF5A2 and certain ribosomal proteins, boosting glycolysis and tumor growth. The findings show these compounds have opposite effects in normal versus cancerous cells and point to targeting eIF5A2 as a potential cancer therapy while preserving any anti-aging benefits.
New research from Tokyo University of Science shows polyamines—long linked to anti-aging effects via autophagy and mitochondria—can promote cancer by upregulating the translation factor eIF5A2 and boosting glycolysis, while altering ribosomal protein production. The study found polyamines lift suppression of eIF5A2 by miR-6514-5p, activating a cancer-promoting program distinct from eIF5A1’s aging-related role, suggesting context matters for polyamine supplements and identifying a potential target for cancer therapy.
Researchers have developed a new method for identifying functional groups in microbial communities without relying on annotation. The method, called "functional group discovery," uses statistical analysis to identify groups of microbes that share similar metabolic pathways and ecological roles. The researchers used the method to identify groups involved in nitrogen cycling and polyamine production in gut microbiomes. The approach could help researchers better understand the ecological roles of microbes in complex communities.