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New Antibiotic Class

All articles tagged with #new antibiotic class

healthscience1 year ago

"Novel Antibiotic Class Defeats Resistant Blood Infections in Mice"

Researchers at Uppsala University in Sweden have identified a new class of antibiotics that targets an enzyme essential to the functioning of gram-negative bacteria, which are known for their resistance to antibiotics. In tests on mice, the antibiotic showed promise in eliminating drug-resistant E. coli and K. pneumoniae infections with just one dose, offering hope in the fight against antibiotic resistance. The study's findings are significant as gram-negative bacteria pose a major threat due to their resistance to broad-spectrum antibiotics, and the new antibiotic class could potentially address this critical health challenge.

healthscience1 year ago

"Discovery of Effective New Antibiotic Class Against Multidrug-Resistant Bacteria"

Scientists at Uppsala University have discovered a new class of antibiotics that effectively targets multidrug-resistant bacteria, curing bloodstream infections in mice. The antibiotics target a protein used by Gram-negative bacteria to synthesize their outermost layer of protection, and have shown promise in treating bacteria resistant to existing antibiotics. This discovery is a significant step in combating antibiotic resistance and was supported by the EU project ENABLE.

health-and-medicine2 years ago

"Revolutionary Antibiotic Emerges to Combat Drug-Resistant Superbugs"

Researchers have developed a new class of antibiotics, tethered macrocyclic peptides (MCPs), targeting the lipopolysaccharide (LPS) transporter in bacteria, specifically inhibiting the LptB2FGC complex. The clinical candidate, zosurabalpin (RG6006), has shown potent activity against carbapenem-resistant Acinetobacter baumannii (CRAB), a critical pathogen with limited treatment options. This novel antibiotic class effectively treats drug-resistant bacterial infections in vitro and in mouse models, representing a significant advancement in combating antibiotic resistance and providing a new treatment option for invasive CRAB infections.