All articles tagged with #menin
Researchers at Monash University (with Harvard) found that targeting epigenetic proteins Menin and DOT1L can permanently switch off cancer-driving genes in certain leukemias, a finding that could enable shorter, less toxic therapies and is moving toward clinical trials later this year.
A recent study suggests that the decline of Menin in the hypothalamus may contribute to physiological aging, affecting cognition, bone mass, skin thickness, and lifespan. The study found that a simple dietary supplement of an amino acid, D-serine, may help mitigate some of these age-related changes. The decline in the hypothalamic Menin may play a key role in aging, and the findings reveal a previously unknown driver of physiological aging.
A new study in mice has identified a previously unknown trigger of aging in the brain's hypothalamus, involving the age-related reduction of a protein called menin. The study suggests that a reduction in menin in the hypothalamus results in neuroinflammation that may cause characteristics of aging. The authors of the study also determined that a loss of menin causes a reduction in levels of an enzyme required for the production of the neurotransmitter, the amino acid D-serine. The study proposes that supplements of menin and D-serine may be able to reverse aspects of aging in humans.
A new study reveals that the decline of the hypothalamic hormone Menin may play a key role in aging. Researchers found that supplementing the amino acid D-serine helped to mitigate some of the age-related changes associated with a decline of Menin in mouse models. The study suggests that supplementation with D-serine may mitigate some age-related changes and reverse signs of physiological aging, including improved skin thickness and bone mass, better learning, cognition, and balance.
Loss of Menin in the hypothalamus may contribute to aging-related phenotypes, including cognitive decline, bone mass reduction, and skin thickness reduction. A dietary supplement, D-serine, can reverse some of these age-related changes in mice by increasing Menin and D-serine levels in the hypothalamus. The study suggests that Menin may be a key protein connecting genetic, inflammatory, and metabolic factors of aging and that D-serine is a potentially promising therapeutic for cognitive decline.
A new study suggests that the loss of Menin, a hypothalamic hormone, may play a key role in aging. Reduction of Menin in younger mice led to an increase in hypothalamic neuroinflammation, aging-related phenotypes, cognitive decline, and modestly reduced lifespan. The study also found that dietary supplementation with D-serine, an amino acid, can reverse some age-related changes in mice, including improved skin thickness and bone mass, better learning, cognition, and balance. The findings reveal a previously unknown driver of physiological aging and suggest a potentially promising therapeutic for cognitive decline.