All articles tagged with #ido1
Scientists at the University of Texas at Arlington discovered that blocking the enzyme IDO1 can restore macrophages' ability to process cholesterol during inflammation, potentially preventing diseases like heart disease, diabetes, and cancer. Targeting IDO1 and nitric oxide synthase could lead to new treatments for inflammation-related illnesses.
New research has revealed important information about how aspirin works, shedding light on its mechanism of action and cellular targets. Aspirin inhibits the cyclooxygenase enzyme (COX), which creates messenger molecules that are crucial in the inflammatory response. The study found that aspirin controls transcription factors required for cytokine expression during inflammation while also influencing many other inflammatory proteins and noncoding RNAs that are critically linked to inflammation and immune response. Aspirin also slows the breakdown of the amino acid tryptophan into its metabolite kynurenine by inhibiting associated enzymes called indoleamine dioxygenases, or IDOs. The researchers predict that COX inhibitors might also be useful as drugs for immunotherapy.
Researchers at the University of Texas at Arlington have discovered new ways in which aspirin reduces inflammation by inhibiting enzymes called cyclooxygenase (COX) and slowing the breakdown of the amino acid tryptophan. This could pave the way for creating safer treatments for inflammation and cancer. The interplay between COX and IDO1 during inflammation could be important for treating other kinds of illness beyond the typical indications for aspirin, such as immunotherapy treatments that target IDO1. The team is now trying to create small molecules in the lab that similarly inhibit COX/IDO1 for potential anti-inflammatory and immunotherapy drugs.
Scientists have discovered more about how aspirin works, including its mechanism of action and cellular targets. Aspirin inhibits the cyclooxygenase enzyme, or COX, which creates messenger molecules crucial in the inflammatory response. The researchers found that aspirin controls transcription factors required for cytokine expression during inflammation while also influencing many other inflammatory proteins and noncoding RNAs that are critically linked to inflammation and immune response. They also showed that aspirin slows the breakdown of the amino acid tryptophan into its metabolite kynurenine by inhibiting associated enzymes called indoleamine dioxygenases, or IDOs. Aspirin's potential interplay between COX and IDO1 during inflammation suggests that COX inhibitors might also be useful as drugs for immunotherapy.