New Insights into Aspirin's Mechanism of Action Uncovered by Scientists
Researchers at the University of Texas at Arlington have discovered new ways in which aspirin reduces inflammation by inhibiting enzymes called cyclooxygenase (COX) and slowing the breakdown of the amino acid tryptophan. This could pave the way for creating safer treatments for inflammation and cancer. The interplay between COX and IDO1 during inflammation could be important for treating other kinds of illness beyond the typical indications for aspirin, such as immunotherapy treatments that target IDO1. The team is now trying to create small molecules in the lab that similarly inhibit COX/IDO1 for potential anti-inflammatory and immunotherapy drugs.