Tag

Heterogeneity

All articles tagged with #heterogeneity

health-genetics1 year ago•105 min saved

Uncovering Genetic Markers Driving Type 2 Diabetes Heterogeneity

A study on type 2 diabetes (T2D) pathophysiology reveals genetic heterogeneity in T2D development and complications. The research, involving over 2.5 million individuals of diverse ancestry, identified 1,289 T2D association signals and classified them into eight mechanistic clusters based on their cardiometabolic profiles. The study also uncovered ancestry-correlated heterogeneity in allelic effects at T2D association signals, with differences in mean BMI in T2D cases and controls across ancestry groups playing a role. Additionally, the study tested the association of cluster-specific polygenic scores with T2D-related vascular outcomes, providing insights into the genetic drivers of T2D heterogeneity.

via Nature.com|

#diabetes #genetic-drivers #gwas

science-and-technology2 years ago•3 min saved

Israeli researchers solve 50-year-old stability puzzle in networks.

Researchers from Bar-Ilan University have solved the diversity-stability paradox, a question that has plagued scientists for over five decades. The paradox asks how complex networks remain stable despite external disruptions. The researchers found that the missing piece of the puzzle is that the patterns of interaction in social, biological, and technological networks are highly non-random and heterogeneous. This heterogeneity enhances stability and explains why most networks exhibit highly resilient functionality despite enduring constant perturbations and obstructions. The findings can offer new guidelines for designing stable infrastructure networks that can protect against viable threats and strengthen the resilience of crucial ecosystems.

via The Jerusalem Post|

#bar-ilan-university #complex-networks #diversity-stability-paradox

science2 years ago•3 min saved

50-year-old puzzle of network stability solved by Israeli researchers

Researchers from Bar-Ilan University in Israel have solved the diversity-stability paradox, a 50-year-old puzzle in ecology, by showing that the heterogeneity of interaction patterns in social, biological, and technological networks enhances stability and makes them extremely robust against external forces. Large and heterogeneous complex networks not only can be stable, but, in fact, they often must be stable. This discovery can offer new guidelines for designing stable infrastructure networks that can protect against viable threats and strengthen the resilience of crucial ecosystems.

via Phys.org|

#complex-systems #ecology #heterogeneity