All articles tagged with #hematopoietic stem cells
Mount Sinai researchers found that aging in hematopoietic stem cells is driven by hyperactive lysosomes; by inhibiting lysosomal activity in aged cells ex vivo, they restored youthful function and boosted in vivo blood-forming capacity by over eightfold, offering a potential path to treating age-related blood disorders and improving stem cell transplants.
A study conducted by researchers at UC San Diego suggests that stem cell transplants using hematopoietic stem cells could be a promising therapeutic avenue for Alzheimer's disease. In a mouse model, mice that received healthy stem cell transplants showed preserved memory and cognition, reduced neuroinflammation, and significantly less β-amyloid build-up compared to untreated mice. The success of the therapy is attributed to its effects on microglia, a type of immune cell in the brain. The transplanted stem cells differentiated into microglia-like cells, leading to enhanced microglia health and protection against multiple levels of Alzheimer's pathology. Further research is needed to understand the mechanisms behind these improvements and explore the potential of this therapy in humans.