Calming the Cell's Recycling Centers Rejuvenates Blood Stem Cells
Mount Sinai researchers found that aging in hematopoietic stem cells is driven by hyperactive lysosomes; by inhibiting lysosomal activity in aged cells ex vivo, they restored youthful function and boosted in vivo blood-forming capacity by over eightfold, offering a potential path to treating age-related blood disorders and improving stem cell transplants.