All articles tagged with #endothelial cells
A new study proposes that viruses like COVID-19 induce endothelial cell senescence, leading to blood clotting, reduced blood flow, and symptoms like brain fog and fatigue in long-COVID and ME/CFS patients. The research aims to develop diagnostic tools and targeted therapies by identifying 'zombie' blood vessel cells, potentially improving treatment for these chronic conditions.
New research suggests that viruses like COVID-19 can induce endothelial cells to become 'zombie' senescent cells, which contribute to long-lasting symptoms such as fatigue, brain fog, and blood flow issues in long-COVID and ME/CFS by promoting blood clots and immune dysfunction. The study aims to develop diagnostic tools and targeted therapies to eliminate these senescent cells and improve patient outcomes.
A new study suggests that erythritol, a common sugar substitute, may impair brain blood vessel function by increasing oxidative stress, reducing nitric oxide production, promoting vessel constriction, and impairing clot dissolution, potentially raising stroke risk, though further research is needed to confirm these effects in humans.
Researchers from the University of Illinois at Chicago have identified the protein Nucleoporin93 (Nup93) as crucial for maintaining endothelial cell health and preventing vascular aging. The study, published in the journal Aging, suggests that restoring Nup93 levels can reverse damage in blood vessels, offering potential new therapies for cardiovascular diseases. The research highlights the role of Nup93 in regulating molecular exchanges within cells and preventing harmful protein build-ups, which could lead to innovative treatments for age-related vascular conditions.
Scientists have developed a "blood-vessel-on-a-chip" to study how snake venom causes internal bleeding and to aid in the creation of new antivenoms. This 3D model mimics human blood vessels and reveals how different venoms damage them, potentially reducing the need for animal testing and improving snakebite treatments.
A new study has identified five biological pathways regulated by a few genes that could potentially play a prominent role in coronary artery disease through their involvement in endothelial cell function, including the gene TLNRD1. These findings could lead to the development of novel therapies targeting endothelial cell dysfunction in coronary artery disease, which is the leading cause of death in the United States. The study used high-throughput molecular biology techniques and computational methods to identify major biological pathways and novel genes involved in endothelial cell function that could contribute to the risk of coronary artery disease. This approach could facilitate the discovery of novel biological pathways associated with other diseases as well.