"Revolutionary New Reaction Unveiled in Click Chemistry Research"

1 min read
Source: Chemistry World
"Revolutionary New Reaction Unveiled in Click Chemistry Research"
Photo: Chemistry World
TL;DR Summary

Chemists John Moses and Barry Sharpless have developed a new technique called phosphorus fluoride exchange (PFEx) that enables scientists to easily build oxygen and nitrogen-linked products from a central phosphorus hub. The PFEx reaction is done under mild conditions and operates orthogonally to other click reactions, allowing the new technique to function harmoniously alongside established reactions. The researchers hope that greater diversity in clicked molecules will lead to discoveries, including new bioactive molecules.

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