All articles tagged with #cellular stress
A study from the University of Oxford reveals that sleep may be triggered by electrical stress in mitochondria within brain cells, which leak electrons when overloaded, signaling the brain to initiate sleep to prevent cellular damage. This discovery links energy metabolism directly to sleep regulation and could impact understanding of fatigue, aging, and neurological disorders.
Scientists discovered that depleting cysteine in mice causes rapid, significant weight loss by disrupting energy metabolism and activating stress responses, highlighting cysteine's crucial role in cellular energy production and potential implications for future weight loss strategies.
Researchers at Goethe University Frankfurt have discovered how mitochondria communicate with the cell when under stress. Mitochondria release reactive oxygen compounds and block the import of protein precursors, causing them to accumulate in the cell. This triggers a chemical change in a protein called DNAJA1, which then interacts with the folding assistant HSP70. HSP70 takes care of the misfolded protein precursors, reducing its interaction with its regular partner HSF1. HSF1 is then released and can trigger the cell's anti-stress mechanism for the mitochondria. The study sheds light on the intricate signaling pathways between mitochondria and cells during times of stress.