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Cellular Biology

All articles tagged with #cellular biology

technology2 years ago

"Browser-Based Simulation of Cellular Biology"

Researchers have simulated a "minimal" cell with 493 genes in TypeScript to run in a web browser, aiming to reproduce the JCVI-syn3A bacteria's behavior. The simulation models DNA transcription, mRNA translation, metabolic reactions, and more using chemical and differential equations. While the current simulation lacks cell cycle mechanics and runs on a single thread, it presents an intriguing intersection of in-depth biology and complex simulations, with potential for performance improvements and further development.

via Hackaday|
#cellular-biology#github#simulation
science-and-technology2 years ago

Unveiling the Mysteries of Cellular Biology's "Dark Matter"

Researchers at the University of Montreal have developed a novel fluorogenic probe that allows for the visualization of interactions between sugars and proteins, which are crucial for understanding various biological processes and diseases. Sugars, found in all living cells, play a fundamental role in maintaining health and preventing disease. The probe enables the detection of transient and weak interactions between sugars and lectins, a family of proteins, providing valuable insights into disease processes. This discovery offers a new tool for studying biological interactions and has potential applications in various fields.

via SciTechDaily|
#biological-interactions#cellular-biology#fluorogenic-probe
science-and-technology2 years ago

"Harvard Geneticist Jason Buenrostro Receives Prestigious MacArthur Grant"

Jason Buenrostro, a 35-year-old associate professor at Harvard University, has been named a MacArthur "genius" fellow for his research on gene regulation. Buenrostro pioneered a technique called ATAC-seq, which is used to study how cells regulate gene expression. The method has become a standard tool in research on chromatin accessibility and has applications in understanding cellular processes, biomedicine, drug discovery, and cancer research. Buenrostro is also working on developing DNA sequencing methods to better understand how spatial context impacts cellular function. He is excited about the future of the field and believes that studying epigenomics can provide unique opportunities for developing therapies and saving lives.

via STAT|
#atac-seq#cellular-biology#gene-regulation
science2 years ago

"Revolutionary Breakthrough: Antioxidant Enzymes Repair DNA Damage, Transforming Cellular Biology"

Researchers have made a profound paradigm shift in cellular biology by discovering that the cell nucleus is metabolically active and can protect DNA integrity by mobilizing antioxidant enzymes in response to DNA damage. This finding has significant implications for cancer research, as cancer cells often exploit metabolic processes for their growth. The study identified metabolic enzymes and processes essential for a cell's DNA damage response, revealing that reactive oxygen species accumulate in the nucleus during DNA damage. The enzyme PRDX1 was found to repair the damage and regulate the availability of aspartate, a critical raw material for DNA synthesis. The findings suggest new strategies for cancer treatment, such as combining chemotherapy drugs with agents that boost reactive oxygen species generation or inhibit nucleotide synthesis processes.

via SciTechDaily|
#antioxidant-enzymes#cancer-research#cellular-biology
science2 years ago

Discovery of New Phosphate-Storing Organelle in Fruit Fly Intestines.

Researchers have discovered a new type of organelle in animal cells that acts as a reservoir of phosphate, a molecule essential to life. The organelle helps regulate levels of the nutrient inside cells and triggers processes that maintain tissues when it is in short supply. The discovery was made in fruit-fly intestinal cells, which are a useful model for studying how diseases affect cells in the human intestine. The findings lay the groundwork for exploring whether there are similar phosphate-storing organelles in other animals, including humans.

via Nature.com|
#cellular-biology#fruit-flies#organelles