Tag

Amyloids

All articles tagged with #amyloids

health-neuroscience1 year ago

"Breakthrough Sensor Enables Early Alzheimer's Detection"

Researchers have developed a novel fluorescence imaging technique using a sensor array of coumarin-based molecular probes to detect amyloids, key biomarkers in neurodegenerative diseases like Alzheimer’s and Parkinson’s. This breakthrough offers a simpler alternative to PET scans and could enable earlier diagnosis and a better understanding of these diseases, potentially paving the way for new treatment strategies. The sensor array showed high sensitivity and selectivity in detecting various amyloids, and it could distinguish between different conditions and stages of Alzheimer’s, offering a non-invasive diagnostic method with significant potential for clinical applications.

science-and-technology2 years ago

Unveiling the Molecular Pathology of Neurodegenerative Diseases through Cryo-EM Analysis of Amyloids

Cryo-electron microscopy (cryo-EM) has been instrumental in understanding the molecular pathology of neurodegenerative diseases such as Alzheimer's disease. By analyzing amyloid filaments at atomic resolution, researchers have identified the structural characteristics of these protein aggregates, including tau filaments in Alzheimer's disease. Cryo-EM has provided valuable insights into the formation and organization of amyloid fibrils, shedding light on the underlying mechanisms of neurodegeneration.