Unveiling the Molecular Pathology of Neurodegenerative Diseases through Cryo-EM Analysis of Amyloids

Cryo-electron microscopy (cryo-EM) has been instrumental in understanding the molecular pathology of neurodegenerative diseases such as Alzheimer's disease. By analyzing amyloid filaments at atomic resolution, researchers have identified the structural characteristics of these protein aggregates, including tau filaments in Alzheimer's disease. Cryo-EM has provided valuable insights into the formation and organization of amyloid fibrils, shedding light on the underlying mechanisms of neurodegeneration.