"Developing a Breakthrough Method for Constructing Human Artificial Chromosomes"

Researchers at the Perelman School of Medicine at the University of Pennsylvania have developed a novel technique for creating human artificial chromosomes (HACs) that bypasses previous technical obstacles. This breakthrough method involves crafting HACs from single, long constructs of designer DNA, allowing for quicker and more precise formation of HACs. The potential applications of this technique include advanced gene therapies for diseases like cancer and large-scale genetic engineering of cells for biotechnology. The study, published in Science, demonstrates the efficiency of the new method and its potential for improving engineered cell therapies.