Affordable Microscope Delivers High-Resolution Images for Democracy in Microscopy

Researchers at the University Medical Center Göttingen in Germany have developed a new microscopy technique called ONE microscopy that can achieve resolutions below 1 nm, revealing the shape of individual proteins. The technique combines the physics-beating super-resolution methods and expansion microscopy to offer a level of detail that eclipses even that of multi-million-dollar ‘super-resolution’ microscopes. The ONE microscopy technique is straightforward to apply and works with now-antiquated fluorescent microscopes from the 1990s, making it accessible to researchers in low and middle-income countries.