"Unveiling the Complete Neural Map of the Mouse Brain"

Researchers from the Chinese Academy of Sciences have unveiled the most extensive single-neuron projectome database to date, featuring over 10,000 mouse hippocampal neurons, providing unprecedented insights into the spatial connectivity patterns crucial for understanding learning, memory, and emotional processing in the hippocampus. By employing machine learning algorithms and integrating spatial transcriptome data, the study identified 43 distinct projectome cell types, revealing intricate projection patterns and soma locations’ correspondence to projection targets. This work lays the structural foundation for advancing our knowledge of hippocampal functions and their molecular underpinnings, and the database is accessible through the Digital Brain CEBSIT portal.