Sound World: Chronic Back Pain Amplifies Everyday Noises, Reversable with Brain-Based Therapy

New fMRI study shows chronic back pain heightens the brain’s response to ordinary sounds, with stronger activity in the auditory cortex and insula and less regulation by the medial prefrontal cortex; 142 patients vs 51 controls reacted more intensely than 84% of controls. A randomized trial found Pain Reprocessing Therapy (PRT) best reduced this sensory amplification and normalized brain activity, supporting the idea that chronic pain is a whole-brain issue that can be treated with brain-based therapies.