Retinal Chlamydia pneumoniae Tied to Faster Alzheimer’s Progression

A Cedars-Sinai study found the pneumonia-causing bacterium Chlamydia pneumoniae in the retina, with higher bacterial loads in individuals with Alzheimer’s disease; the bacteria may amplify brain pathology by triggering the NLRP3 inflammasome, increasing inflammation and amyloid beta, and the retina could serve as a noninvasive biomarker for disease status while anti-inflammatory or antibiotic strategies are being explored, though questions remain about how and when infection occurs.