Parkinson’s Disease Reconceived as a Somato-Cognitive Action Network Disorder

A large, multi-modal study proposes Parkinson’s disease as a somato-cognitive action network (SCAN) disorder, showing PD features SCAN-to-subcortex hyperconnectivity that is reduced by dopaminergic therapy and various neuromodulation methods (DBS, MRgFUS, TMS, adaptive DBS). Targeting SCAN nodes—especially cortical SCAN regions—yields greater symptom relief than conventional effector-area targets, suggesting a circuit-based pathophysiology and treatment strategy, with SCAN connectivity serving as a potential biomarker and guide for personalized therapy.