Mutant grin2a reveals thalamocortical circuit linked to cognitive deficits in schizophrenia
TL;DR Summary
MIT researchers link a grin2a gene mutation to impaired updating of beliefs in mice via disruption of a mediodorsal thalamus–prefrontal cortex circuit, slowing adaptive decision-making; optogenetic activation of the circuit reversed the behavioral deficits, suggesting circuit-based targets for cognitive symptoms in schizophrenia.
- Brain circuit needed to incorporate new information may be linked to schizophrenia MIT News
- Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia Nature
- Gene Linking Schizophrenia to Decision-Making Found Neuroscience News
- Reduced Thalamus Activity Drives Abnormal Beliefs in Schizophrenia Bioengineer.org
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