Brain-Skin Nerve Circuit Ties Stress to Eczema Flares

A Science study shows a brain-to-skin neural circuit where stress activates sympathetic nerves that drive eosinophils, worsening eczema. In mice, reducing eosinophils diminished the stress-related flare, while in humans higher stress correlated with more inflammation and eosinophils, suggesting potential therapies that target this neuroimmune pathway to alleviate eczema symptoms.