Mitochondrial Gene Editing Uncovers Memory and Metabolic Links

Researchers at Korea University College of Medicine used mitochondrial gene editing to induce mutations in the ND5 gene in mice, revealing significant impacts on brain function, metabolism, and thermoregulation. The study found that these mutations led to learning deficits, hippocampal atrophy, and obesity, highlighting the potential of mitochondrial gene editing for developing therapies for mitochondrial diseases and related neurodegenerative and metabolic disorders.