Four Transcription Factors May Rejuvenate Aging Cells

A UCSF study identifies four transcription factors (E2F3, EZH2, STAT3, ZFX) that, when modulated, push aging cells toward a younger state; boosting EZH2 in the liver of old mice reduced scarring and improved glucose tolerance, while lab-grown fibroblasts showed rejuvenation-like traits, suggesting a possible universal blueprint for cellular rejuvenation—though long-term safety and broader applicability remain to be confirmed.