Disappearing Y Chromosome Threatens Men's Health and Cancer Outcomes

TL;DR Summary
The Y chromosome is gradually disappearing over millions of years, which could impact male development and health, but some species have evolved alternative mechanisms. In humans, Y chromosome loss already affects a significant portion of men, linked to health risks like cancer and heart disease. Lifestyle choices and medical interventions may help mitigate these effects, while evolutionary biology explores potential future adaptations.
- The Y chromosome is disappearing, and this fact is already causing problems for men Earth.com
- Concurrent loss of the Y chromosome in cancer and T cells impacts outcome Nature
- ‘New realm of biology’: missing Y chromosomes worsen cancer Fierce Biotech
- Loss of Y chromosome “cripples” immune cells, University of Arizona researcher finds Cells with LOY may induce LOY in otherwise healthy cells—a finding that could explain variability in CAR T-cell therapy response The Cancer Letter
- Loss of Y Chromosome Leads to Poor Cancer Outcomes Cedars-Sinai
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