Antioxidant Strategies Enhance T Cell Resistance Against Cancer
TL;DR Summary
Researchers at the University of Pittsburgh discovered that harsh tumor environments damage T cell telomeres via mitochondrial stress and reactive oxygen species, leading to T cell exhaustion. They found that targeted antioxidants can restore T cell function in mice, opening new avenues for improving cancer immunotherapies like CAR-T. The team aims to develop telomere-specific antioxidant treatments for human trials.
- Scientists Find a Way to “Bulletproof” T Cells Against Cancer SciTechDaily
- Antioxidant shield for T cell telomeres shows promise against tumor-induced exhaustion Medical Xpress
- Tumour stress drives T cell exhaustion – antioxidants may reverse it Drug Target Review
- Cancer Immunotherapy Could Be Boosted by Reducing TME-Induced Telomere Damage Inside Precision Medicine
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