Unraveling the Genetic Basis of Stress Response in PTSD and Depression

Researchers have conducted a groundbreaking analysis of genes in over 575,000 brain cells from individuals with and without post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), revealing new insights into the brain's stress response. The study identified specific gene expression changes in the dorsolateral prefrontal cortex (DLPFC) region of the brain, which could serve as potential biomarkers for PTSD and MDD and provide therapeutic targets. The findings may lead to the development of novel treatments and the use of stem cell-derived cells to further study these mechanisms.