"Uncovering the Genetic Basis of Left-Handedness and Neurological Disorders"

A study using UK Biobank data has identified rare variants in the TUBB4B gene significantly associated with left-handedness, shedding light on the genetic basis of this trait and its link to neurodevelopmental disorders. Despite the influence of these rare genetic variants, they account for less than 1% of the heritability of left-handedness, indicating a complex interplay of factors in determining this trait. The findings offer insights into the genetic intricacies of left-handedness and its connection to brain asymmetry and neurodevelopmental disorders, providing new avenues for investigating the developmental pathways leading to brain asymmetry.