Two Brain Subtypes in ADHD Hint at Personalized Treatments

A study using structural MRI and machine learning identifies two distinct physical subtypes of ADHD. Subtype 1 shows increased gray matter in the frontal regions and cerebellum, linked to severe inattention; Subtype 2 shows widespread gray matter reductions in the cerebellum, frontal regions, and hippocampus, tied to higher overall severity and hyperactive/impulsive symptoms. Through a pseudo-time-series analysis and causal-network mapping, researchers reveal subtype-specific brain–behavior progression patterns, suggesting potential for personalized diagnosis and treatment, though longitudinal studies are needed to confirm progression and acknowledge cross-sectional design limitations.