The Link Between High Metabolism and Early Alzheimer's Unveiled

Researchers have discovered that an early sign of Alzheimer's disease is a metabolic increase in the hippocampus, preceding the formation of brain plaques. Using mice with Alzheimer's pathology, the study found increased mitochondrial metabolism followed by synaptic disruptions due to hindered cellular recycling. These metabolic changes could serve as an early diagnostic marker and pave the way for timely interventions. The findings highlight the importance of retaining functional mitochondria and normal protein metabolism in the development of Alzheimer's disease.