Sex Differences in Gray Matter Atrophy During Aging.

A recent study has found that gray matter volume in various cortical areas decreases by an average of 5.25% per decade, with the rostral anterior cingulate cortex experiencing the most significant reduction. Men generally experience a higher rate of gray matter volume decrease than women, particularly in the cingulate lobe. The study's findings provide a normative reference for clinical conditions that involve abnormal brain atrophy, emphasizing the need for personalized and targeted strategies to manage age-related brain volume loss.