Glutamate Imbalance Linked to Psychotic Disorders in Meta-Analysis.

People with a genetic risk for psychosis have an imbalance of glutamate and GABA neurotransmitters in their brains, specifically in the hippocampus, which is associated with hippocampal atrophy and may lead to the development of psychotic symptoms. The study suggests that changes in the hippocampus may drive downstream pathology and that preventing excitatory-inhibitory imbalance and volume loss could potentially mitigate the cognitive decline typically observed in psychotic patients.