Brainstem Circuits as Key Regulators of Chronic Pain and Need-State Control
TL;DR Summary
The study identifies Y1 receptor-expressing neurons in the lateral parabrachial nucleus as key modulators of long-term pain, showing that their activity correlates with persistent pain states and can be suppressed by need states like hunger and thirst through NPY signaling, which gates nociceptive input to promote survival.
- A parabrachial hub for need-state control of enduring pain Nature
- It's all in your head: Select neurons in the brainstem may hold the key to treating chronic pain Medical Xpress
- Hunger, Fear, and the Brain’s Hidden Switch to Turn Off Chronic Pain Neuroscience News
- Parabrachial Hub Governs Persistent Pain States Bioengineer.org
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