New Study Finds No Connection Between PPIs and Dementia.

A post hoc observational study within the Aspirin in Reducing Events in the Elderly (ASPREE) clinical trial found no increased risk for dementia or cognitive changes in older adults aged 65+ who used proton pump inhibitors (PPIs) or histamine-2 receptor antagonist (H2RA). The study concluded that long-term use of PPIs in older adults is unlikely to have negative effects on cognition. However, the study had limitations, including potential for residual confounding and underestimation of PPI and H2RA use.