Unveiling the Role of Spine Stem Cells in Bone Cancer Metastasis

Researchers have discovered a specific type of stem cell in the spine that secretes a protein, MFGE8, which attracts cancer cells and explains why certain types of cancer spread more frequently to the spine than to other bones. This finding could lead to the development of new orthopedic and cancer treatments. The study also suggests that many spine disorders, including osteoporosis, may be linked to the distinct properties of vertebral bone stem cells. The researchers are now exploring ways to block MFGE8 to reduce the risk of spinal metastasis in cancer patients and investigating the role of these stem cells in responding to spine fusion surgery.