The Impact of APOEε4 on Longitudinal Tau Pathology Amplified by Amyloid β

A study has found that the APOEε4 gene variant, a major risk factor for Alzheimer's disease, enhances the effects of amyloid-β on the progression of tau pathology in the brain. The research, conducted on a large cohort of individuals, suggests that APOEε4 may contribute to the development and severity of Alzheimer's disease by exacerbating the accumulation of tau tangles, a hallmark of the disease. These findings highlight the importance of understanding the interaction between amyloid-β and tau in Alzheimer's pathology and may aid in the development of targeted therapies and improved biomarkers for the disease.