All articles tagged with #amyloid b
Researchers at Cold Spring Harbor Laboratory found that inhibiting the enzyme PTP1B improves brain microglial function and helps clear amyloid-β plaques in mice, potentially slowing memory decline in Alzheimer's disease. The study suggests PTP1B inhibitors could be paired with existing therapies, with ongoing work to develop such inhibitors for clinical use.
A study has found that the APOEε4 gene variant, a major risk factor for Alzheimer's disease, enhances the effects of amyloid-β on the progression of tau pathology in the brain. The research, conducted on a large cohort of individuals, suggests that APOEε4 may contribute to the development and severity of Alzheimer's disease by exacerbating the accumulation of tau tangles, a hallmark of the disease. These findings highlight the importance of understanding the interaction between amyloid-β and tau in Alzheimer's pathology and may aid in the development of targeted therapies and improved biomarkers for the disease.