"Autophagy protein p62: A Key Factor for Survival in Sporadic ALS"

Accumulation of p62 protein, involved in the autophagy process, in the spinal cord is associated with worse survival outcomes in individuals with sporadic amyotrophic lateral sclerosis (ALS). The buildup of p62 clumps indicates impaired autophagy, leading to the improper clearance of toxic protein aggregates contributing to ALS. The study suggests that p62 could serve as a potential prognostic biomarker in ALS.