"Immune Attack on Blood-Brain Barrier Linked to Alzheimer's"

A new study has identified a genetic variant, P460L, which disrupts the function of the EphA1 gene and is linked to an increased risk of late-onset Alzheimer's. This variant affects the immune system's response and compromises the blood-brain barrier, potentially leading to the targeting of healthy brain cells by T cells. The findings provide insight into how Alzheimer's may damage brain cells and suggest potential therapeutic targets for treating the disease in the future.